In spite of their being wide-spread and common, the traditional methods of standard case-control studies analyses through logistic reversion do not permit the evaluation of time-varying links between exposures and the outcome. Therefore, this work uses a vaccine efficiency study as the inspiration to introducing two novel methods that would make time-varying links evaluation possible. Through the implementation of these new methods, time-varying links between exposure and outcome could be evaluated in fields where they have not been detected before. Furthermore, in contrast to logistic reversion method, case-cohort analyses permit the evaluation process of time-varying links as a constant function of time, which makes it a more appropriate and effective approach for time-varying association assessment.